- Tournament Edition: "The Netherrealm demon, Sareena, lost her human form in an attack from the fallen Elder God, Shinnok. She was transposed back into her demon form as her essence descended back to the Fifth plane of the Netherealm. Sareena remained there until she discovered an abandoned portal that led to Outworld. Once in Outworld, she learned to feed off of the living aura of that realm to regain her human appearance. She no longer needed Quan Chi's sorcery to sustain her exterior beauty."
- Armageddon Bio Kard: "Once one of Quan Chi's elite lieutenants, the demon Sareena had a change of heart, offering to help Sub-Zero to defeat her sorcerer master. This betrayal cost her human form and brought her years of suffering in the Netherrealm. Now free, she has regained her mortal form and has pledged to Sub-Zero and the Lin Kuei."
- Armageddon: "I was given asylum by the Lin Kuei in gratitude for aiding Sub-Zero in the Netherrealm years ago. I swore to uphold the laws of the clan and protect it from any outside threat. My allegiance was strong, but Sub-Zero felt I still had much to prove before the clan would fully accept me. He entrusted me with a small metallic object that would guide me and grant me access to the hidden Lin Kuei temple. He ordered me to wait for him there as he departed for the Netherrealm. Instead, I followed him -- I could not bring myself to allow him to come to harm. But the realm's essence began twisting my soul, and I had second thoughts about disobeying him. When he was attacked by Noob Saibot and Smoke, however, it seemed I had made the right decision. I leapt from hiding and prevented Noob from killing Sub-Zero. With the sides now even, we soundly defeated Noob and Smoke. They escaped to parts unknown, but not before rendering Sub-Zero unconscious. The intense fight and the influence of the Netherrealm's dark energies caused me to lose control of my human apperance, and I reverted to my demonic form. When Sub-Zero regained consciousness, he was confused and attacked me. To avoid harming him, I fled to the depths of the Netherrealm. There I was ambushed by Noob, Smoke, and my former master, Quan Chi. The sorcerer knew of my allegiance to Sub-Zero and demanded to know the location of the Lin Kuei temple. At first I refused, holding to my oath. But Quan Chi's influence is great. He cast his dark sorcery upon me, returning me to my human form and showing me my true nature. I am not a being of Light. I am a demon of the Netherrealm, a servant of Quan Chi. I will follow him to whatever end. I surrendered the object given to me by Sub-Zero. He was a fool to have trusted me."
The demon Sareena first appeared in Mortal Kombat Mythologies: Sub-Zero as one of Quan Chi's personal assassins. She and her two partners, Kia and Jataaka, were ordered to kill Sub-Zero before he reached Quan Chi. They were defeated, but Sub-Zero strangely spared Sareena's life. Later, as Sub-Zero battled Quan Chi, Sareena suddenly appeared and helped him to defeat the sorcerer. After expressing her desire to escape the Netherrealm with him, she is shot in the back with a bolt of energy by Shinnok. She collapses into an enraged Sub-Zero's arms and appears to die.
It is later revealed in Mortal Kombat: Tournament Edition that Sareena was not killed by Shinnok's attack, but rather her human form was destroyed. Her essence was then banished to the Fifth Plane of the Netherrealm as punishment for her betrayal, where she would suffer for years. After years of being trapped, Sareena discovered the portal Quan Chi and Scorpion used to escape the Netherrealm shortly before Mortal Kombat: Deadly Alliance. She went through the portal and is transported to Outworld where she later discovered a way to restore her human form without Quan Chi's magic by absorbing the energy of the realm.
Shortly after regaining her human form, Sareena encountered the younger brother of the Sub-Zero she met years before. Feeling that he owed her for helping his brother, Sub-Zero granted her sanctuary with the Lin Kuei back on Earthrealm. In gratitude, Sareena pledged her loyalty to the clan, swearing to help defend it from its enemies.
In Mortal Kombat: Armageddon, it is revealed that Sareena followed Sub-Zero into the Netherrealm, saving him from being killed by Noob Saibot and Smoke. She and Sub-Zero were victorious, but after the battle, Sareena lost control of her human form and returned to her true demon self. Thinking her to be a threat, Sub-Zero attacked and she fled, not wanting to harm him. However, she was later attacked by Noob Saibot, Smoke, and her former master Quan Chi, who demanded she provide them the metallic item necessary to enter the Lin Kuei Temple. At first, Sareena refused, determined to remain loyal to Sub-Zero. But Quan Chi then cast his dark sorcery upon her, returning her to her human form and then convincing her that she can never be good and that she is simply a pure evil demon. Swayed by Quan Chi's corruption, she agreed to serve him once again.
In Mortal Kombat: Armageddon's Konquest mode, Taven encounters Sareena, still serving Quan Chi alongside Kia and Jataaka in the Red Dragon's lair. They battle, but all the three assassins are ultimately defeated by the half-god. However, Sareena was once again spared. After the battle, Sareena escapes Quan Chi's hold over her.
Sareena would then join the Forces of Light in the final battle and die alongside the other kombatants.
- Tournament Edition (Canonical): "While in Outworld, the demon known as Sareena encountered Sub-Zero. Since she had freed his brother from his confines of the Netherrealm so many years ago, Sub-Zero offered her asylum within the Lin Kuei. His compassion may be honorable, but befriending a demon of the Netherrealm is not an action without risk... as Sub-Zero may soon discover."
- Armageddon (Non-Canonical): "Blaze had dissipated, but the power he had released flowed into Sareena. She lay unconscious atop the pyramid until Sub-Zero revived her. Examining her hands, she found that she had gained the ability...to freeze. Sareena confronted her old master, Quan Chi, and froze him solid. She and Sub-Zero hid the sorcerer in the Lin Kuei temple, where he will remain forever suspended in a block of ice."