In Japan, Hanzo Hasashi is taking his son, Satoshi, back to the Shirai Ryu village. There, they are ambushed by the warriors of the Lin Kuei, who have already slaughtered the entire village. Hanzo is able to counter the ambush and hide in his dojo. Upon entering his room, Hanzo discovers the corpse of his wife Harumi, unleashing a state of berserk rage inside him as he starts to eliminate the remaining warriors of the Lin Kuei inside the dojo. Hanzo looses the notion of space and time, and awakes outside the dojo, with the Lin Kuei's leader Sub-Zero holding Satoshi hostage and threatening to kill him if Hanzo does not surrender. Hanzo does, but Sub-Zero incapacitates him and kills Satoshi regardless by impaling him through the throat, before shooting an icicle through Hanzo's mouth, impaling him through the back of the neck and killing him.
In the Shaolin temple, Raiden tells Liu Kang to prepare himself to the tournament, and other defenders will be reunited with them. In Los Angeles, Johnny Cage, having broken up with his girlfriend, receives a call from his agent, who tells him that he should travel to China for his next job. In China, Sonya Blade engages a thug in a street fight, amid a Special Forces task to locate Kano, where she gets an invitation for the tournament. In the Netherrealm, Hanzo is about to be tortured by Moloch, but manages to free himself and kills the demon. On his search for Shinnok, he eliminates hundreds of demons, before meeting with Quan Chi. Quan Chi tells him that Shinnok was in-disposed and proposes an offer to Hanzo: Join the Mortal Kombat Tournament, which Sub-Zero will attend and complete his revenge, but also retrieve the key to free Shinnok, which is being held at Shang Tsung's Palace, the tournament location. Hanzo accepts, now dubbing himself as 'Scorpion'.
On a boat, Johnny meets with Liu Kang, Sonya and Raiden, as they travel through the vail to reach the Island of Shang Tsung. Upon their arrival, Shang Tsung hosts the attendants. Meanwhile, Scorpion manages to infiltrate inside the treasures of Shang Tsung, but just as he is about to get the key, but is persuaded by Raiden not to take it. Shang Tsung gives a demonstration of the tournament by capturing Jackson "Jax" Briggs and forcing him to fight his champion Goro. Goro succeeds in defeating Jax by ripping both his arms off, but Raiden stops Jax's execution and warns Shang Tsung that this fight was the tournament not been offically started yet. He is able to heal Jax's wounds, but the sorcerer holds him prisoner. Shang Tsung then starts the tournament properly, and uses his magic to teleport the attendants to face each other on the Island.
Johnny is teleported to a tower, where he encounters Baraka, but destroys the tower in the process. Sonya is sent to a swamp, where she fights Reptile and successfully decapitates him with a chain. In a forest, Scorpion kills a lone Lin Kuei warrior. At Shang Tsung's Garden, Liu Kang fights Kitana, but defeats her, although he instead spares her life afterwards. In the wake of Earthrealm's success, Shang Tsung orders the Black Dragon to kill them. Liu Kang reunites with Sonya and Johnny and later, they meet Scorpion after killing a few Black Dragon thugs. Raiden appears and tells them they must enter the throne room to face the final kombatant, but Black Dragon members try to stop them. Upon reaching the bridge that leads to the throne room, the Earthrealmers are ambushed by Kano and Black Dragon assassins. With the help of Scorpion, they manage to defeat the Black Dragon. Kano is confronted by Sub-Zero, who overpowers him, but Scorpion, recognizing the blue-clad ninja as his son's killer, starts to battle him. Kano runs to the torture chamber, but Sonya goes after him, while Johnny decides to help her and Liu Kang goes to the throne room to confront Shang Tsung.
Meanwhile, Scorpion fights Sub-Zero which ends by grabbing the former and resulting in the two hurling themselves off the bridge's cliff, impaling both ninja on a large spike, although Scorpion survives due to him being undead while Sub-Zero is killed. Then, Quan Chi appears and reveals to a badly injured Scorpion that he disguised himself as Sub-Zero and ordered the Lin Kuei soldiers to exterminate the Shirai Ryu since the real Sub-Zero was not actually involved in the carnage while also being the one responsible for murdering Harumi and Satoshi. Before the sorcerer leaves, Scorpion has a thought of Satoshi when he told his son that the Scorpion creature has its will, which made itself stronger. Scorpion then came back from that and removes himself from the spike to exact his redeem revenge. At the torture chamber, Kano is holding Jax hostage, and releases a horde of Outworlders to fight Sonya. They easily outmatch her, but she is saved by Johnny. They are able to defeat the horde, free Jax and finally defeat Kano. As they are about to leave, Jax apparently kills Kano by crushing his head.
Liu Kang reaches the throne, and there he battles Goro. Goro easily outmatches Liu Kang, but before he is about to execute him just like he did to Jax, Scorpion appears and decapitates Goro. Shang Tsung proposes to Scorpion to defeat Liu Kang, in exchange for having Quan Chi. Scorpion tricks Shang Tsung into giving him the key, and ends the tournament, making Liu Kang the champion of Mortal Kombat. Since the tournament ended, Shang Tsung leaves to Outworld and the Island starts to crumble. Raiden and Liu Kang gather with Sonya, Johnny and Jax and leave in the boat. Scorpion stays to battle Quan Chi which ends by successfully killing him, finally avenging Satoshi, Harumi and the fallen Shirai Ryu before the island crumbles in ruins, allowing Scorpion to be crushed by debris as he accepts his fate and joins his clan in the afterlife. As Liu Kang and the Earthrealmers watch the island collapse, he voices regret for failing, but Raiden assures him that his destiny was never to face Goro, but rather the emperor.
In Outworld, Shang Tsung faces Shao Kahn's punishment for failing to win the tournament. Shao Kahn orders him to gather his forces to end the cycles of the tournament.
The following Mortal Kombat characters appears in the movie:
- Joel McHale — Johnny Cage
- Jennifer Carpenter — Sonya Blade
- Jordan Rodrigues — Liu Kang
- Patrick Seitz — Scorpion
- Steven Blum — Sub-Zero
- Artt Butler — Shang Tsung, Lin Kuei Assassin
- Darin De Paul — Quan Chi
- Robin Atkin Downes — Kano
- Dave B. Mitchell — Raiden, Lin Kuei Warrior
- Ike Amadi — Jax
- Kevin Michael Richardson — Goro, Bystander
- Grey Griffin — Kitana, Satoshi Hasashi, Johnny Cage's Ex-girlfriend (uncredited)
- Fred Tatasciore — Moloch, Shao Kahn (uncredited)
The film was set to release in April 12th digitally, but due to unknown reasons, it was pushed to April 14th. The release on DVD and Blu-Ray was released in April 28th.
- This is the first Mortal Kombat movie to receive an R-Rating from the MPAA.
- It is also the first Mortal Kombat property to be produced at Warner Bros. Animation.
- Co-Creator Ed Boon serves as a creative consultant for the movie.
- Liu Kang, Raiden, Kano, Sonya, Scorpion, Reptile, Quan Chi, Kitana, Jax, Goro, Baraka and Oni have their designs based on their Mortal Kombat X standard costume.
- Shang Tsung has his design based on his Mortal Kombat (2011) alternate costume.
- The elder Sub-Zero has his design based on the younger Sub-Zero's Mortal Kombat X standard costume.
- Shao Kahn has his design based on his Mortal Kombat (2011) costume.
- Over the course of the film, there are multiple times when attacks and kills show the X-Ray of the damage.
- It is possible to see a poster of Ninja Mime at Johnny Cage's residence.
- The Demon Torturer has his design based on Moloch.
- Shinnok is mentioned by multiple characters through the film.
- Johnny Cage gives an autograph to a monk on Shang Tsung's Island, making a reference to his Friendship.
- There is a scene where two unknown attendants are challenging Test Your Might.
- Nitara makes a cameo appearance, where she stands by the food along with Johnny Cage. She is seen in her default attire from Mortal Kombat: Deadly Alliance.
- Masked Guards make a cameo appearance, guarding Shang Tsung's treasures.
- While explaining the Mortal Kombat to the combatants, Shang Tsung shows images of the Elder Gods, The Great Kung Lao and his younger self that has the design based on his Mortal Kombat 3 appearance.
- Since the production of the film started before the release of Mortal Kombat 11, Cetrion isn't one of the Elder Gods shown in the film.
- After defeating the Tarkatan, Johnny Cage yells "Toasty!".
- The ship that gardes Sonya Blade, Johnny Cage, Liu Kang and Raiden is part of The Kove.
- The fight of Scorpion against Moloch takes place in Krossroads.
- The fight of Scorpion against Quan Chi takes place in Quan Chi's Fortress.
- The fight of Sonya Blade against Reptile takes place in Kuatan Jungle.
- The fight of Liu Kang against Kitana takes place in Shang Tsung's Garden.
- The fight of Scorpion against Sub-Zero takes place in The Pit.
- The fight of Liu Kang against Goro and later Scorpion against Quan Chi takes place in Shang Tsung's Throne Room.
- The fight of Motaro, TaiGore, Tarkatan, Saurian and other demons against Sonya Blade and Johnny Cage takes place in Goro's Lair.
- Scorpion kills Quan Chi using his classic Flame-breath Fatality from Mortal Kombat.
- The punishment of Shang Tsung by Shao Kahn takes place in the Shao Kahn's Throne Room.
- Kitana's voice actress in the movie, Grey Griffin was originally going to voice the character in Mortal Kombat X but she previously bowed out to the role due to her pregnancy with her second child at the time, leaving Karen Strassman reprising the role instead.
- Goro's voice actor, Kevin Michael Richardson reprises his role for the first time in twenty-five years after voicing him in the 1995 film.
- Patrick Seitz reprises his role as Scorpion after being replaced by Ron Yuan in Mortal Kombat 11.